Haploidentical hematopoietic stem cell transplantation as promising therapy in the improved survival of pediatric patients with leukemias and myelodysplasias

Table 2 Characteristics of haploidentical transplants identified in the studies included

Ref.	All patients, n	Age, yr, median	Sex, male, n	Condition clinic	Haplo transplant cohort, n	Age, yr, median	Sex, male, n	Source of stem cells
Kim et al[15], 2021	24	1.201	15	JMML	14	NR	NR	PBSC
Hong et al[16], 2022	80	NR	51	ALL, AML, MPAL, and NK cell leukemia	35	7.00	22	PBSC
Bertaina et al[17], 2018	343	3.30	210	ALL, AML	98	6.60	65	PBSC5 BM
Bai et al[18], 2020	383	4.00	25	MLL-r B-ALL	194	4.00	13	NR
Ruggeri et al[19], 2021	180	9.25	114	ALL	180	9.25	114	PBSC BM
Sun et al[20], 2015	111	10.00	73	AML, ALL, CML, and MLL	111	10.00	73	PBSC BM
Sano et al[21], 2021	19	10.00	12	RR-BCP-ALL	19	10.00	12	PBSC, PB + BM
Paina et al[22], 2018	106	7.00	65	ALL, AML	106	7.00	65	BM + PBSC BM
Mo et al[23], 2016	129	NR	42	HR, ALL	65	10.00	33	G-BM, G-PB
Wang et al[24], 2020	166	15.00	114	B-ALL and T-ALL	166	15.00	114	NR
Zhang et al[25], 2022	74	11.00	52	HR T-ALL	272	12.00	21	BM
Zheng et al[26], 2020	82	NR	56	HR AML	69	12.00	42	PBSC, BM
Trujillo et al[27], 2021	42	11.00	24	ALL, AML, JMML, and CML	42	11.00	24	PBSC
Yang et al[28], 2022	21	NR	15	AML, KMT2A rearrangents	17	6.06	12	NR
Bai et al[29], 2022	44	9.00	25	MLL-r AML	37	NR	NR	NR
Miyamura et al[30], 2019	90	3.00	49	AML KMT2A rearrangents	10	NR	NR	NR
Oevermann et al[32], 2014	85	10.00	NR	ALL	85	10.00	NR	PBSC
Pérez-Martínez et al[33], 2020	192	8.60	118	ALL, AML, MDS, JMML, CML, and biphenotyipic	192	8.60	118	PBSC BM

¹In the study, this information was given in months.

²Four patients had a matched sibling donor. So, only 23 patients received haplo-hematopoietic stem cell transplantation. However, Zhang et al[25] didn’t give the age and numbers by sex separately.

³One patient was excluded from the analysis owing to death from pulmonary infection during induction. So, only 37 patients were analyzed.

⁴One patient received human leukocyte antigen-MUDT. So, only 18 received the haplo-transplant CR1. However, Bai et al[18] didn’t give the age and numbers by sex separately.

⁵All patients in the haplo cohort received stem cells from peripheral blood stem cells.

JMML: Juvenile myelomonocytic leukemia; ALL: Acute lymphocytic leukemia; AML: Acute myeloid leukemia; CML: Chronic myelogenous leukemia; MLL: Mixed lineage leukemia; MPAL: Mixed-phenotype acute leukemia; NK: Natural Killer; RR-BCP: Relapsed or refractory B-cell precursor acute lymphoblastic leukemia; NR: Not related; PBSC: Peripheral blood stem cells; BM: Bone marrow; PB: Peripheral blood.