Viral hepatitis: A narrative review of hepatitis A–E

Table 3 DAA therapy in pediatric population

Regimen	Patient population	Duration (wk)
Genotype 1
Ledipasvir/sofosbuvir	Prior exposure to DAA and IFN (± ribavirin) , no cirrhosis	12
	Prior exposure to DAA and IFN (± ribavirin) , compensated cirrhosis	24
Glecaprevir/pibrentasvi	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an NS5A inhibitor but no NS3/4A protease inhibitor exposure, no cirrhosis, compensated cirrhosis	16
	Age ≥ 12 yr or weighing ≥ 45 kg with prior exposure to NS3/4A protease inhibitors but no NS5A inhibitor exposure, no cirrhosis, compensated cirrhosis	12
	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, with compensated cirrhosis	12
	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, without cirrhosis	8
Genotype 2
Glecaprevir /pibrentasvir	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, without cirrhosis	8
	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, compensated cirrhosis	12
Genotype 3
Glecaprevir/pibrentasvir	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, no cirrhosis or compensated cirrhosis	16
Genotype 4
Glecaprevir/pibrentasvir	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, compensated cirrhosis	12
	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, no cirrhosis	8
Ledipasvir/sofosbuvir	Age ≥ 3 yr with prior exposure to an IFN (± ribavirin) plus an HCV protease inhibitor regimen, no cirrhosis or compensated cirrhosis	12
Genotype 5
Ledipasvir/sofosbuvir	Age ≥ 3 yr with prior exposure to an IFN (± ribavirin) plus an HCV protease inhibitor regimen, no cirrhosis or compensated cirrhosis	12
Glecaprevir/pibrentasvir	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, no cirrhosis	8
	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, with compensated cirrhosis	12
Genotype 6
Glecaprevir/pibrentasvir	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, no cirrhosis	8
	Age ≥ 12 yr or weight ≥ 45 kg with prior exposure to an IFN-based regimen (± ribavirin) and/or sofosbuvir but no exposure to NS3/4A or NS5A protease inhibitors, with compensated cirrhosis	12
Ledipasvir/sofosbuvir	Age ≥ 3 yr with prior exposure to an IFN (± ribavirin) plus an HCV protease inhibitor regimen, no cirrhosis, compensated cirrhosis	12

DAA: Direct-acting antiviral; IFN: Interferon; HCV: Hepatitis C virus.