Viral hepatitis: A narrative review of hepatitis A–E

Table 1 Approved antivirals for adults and children for chronic hepatitis B

Drug	Adult dosing	Pediatric dosing	Potential side effects	Pregnancy category
Peg-IFN-a-2a (adult) IFN-a-2b (children)	180 mcg wkly	> 1 yr dose: 6 million IU/m2 three times wkly	Flu-like symptoms, fatigue, mood disturbances, cytopenia, autoimmune disorders in adults, anorexia, and weight loss in children	C
Entecavir	0.5 mg daily	> 2 yr dose: weight-based to 10-30 kg; above 30 kg: 0.5 mg daily	Lactic acidosis (decompensated cirrhosis only)	C
Tenofovir dipovoxil fumarate	300 daily	> 12 yr	Fanconi syndrome, osteomalacia, lactic acidosis	B
Tenofovir alafenamide	25 mg daily	-	Lactic acidosis	There are insufficient human data on use during pregnancy to inform a drug-associated risk of birth defects and miscarriage
Lamivudine	100 mg daily	2 yr dose: 3 mg/kg daily to max 100 mg	Pancreatitis lactic acidosis	C
Adefovir	10 mg daily	12 yr	Acute renal failure Fanconi syndrome lactic acidosis	C
Telbivudine	600 mg daily	-	Creatine kinase elevation and myopathy peripheral neuropathy lactic acidosis	B