Is cellular therapy beneficial in management of rotator cuff tears? Meta-analysis of comparative clinical studies

Table 1 Characteristics of included studies (n = 6)

No.	First author	Year	Country	Study design	Sample size	Cases/controls	MSC source	PRP	Cellular dosage (106 cells)	Comparator intervention	Case age (SD)	Control age (SD)	Case male: Female	Control male: Female	Follow-up timeline (mo)
1	P Hernigou	2014	France	RCS	90	45/45	BM-MSC	No	0.051	Surgery	61 ± 4.5	61 ± 4.5	21:24	20:25	6, 120
2	YS Kim	2017	Korea	RCS	70	35/35	AD-MSC	No	4.46	Surgery	59.2 ± 3.4	57.6 ± 2.9	15:20	13:22	28.3
3	SJ Kim	2018	Korea	PCS	24	12/12	BM-MSC	Yes	1	Exercise therapy	54.9 ± 7.6	59.6 ± 7.2	05:07	08:04	0.7, 3
4	JR Lamas	2019	Spain	RCT	13	8/5	BM-MSC	No	20	Surgery	57.8 ± 6.5	61.8 ± 3.8	06:02	02:03	12
5	C Centeno	2020	USA	RCT	25	14/11	BM-MSC	Yes	810	Exercise therapy	46 ± 11	49 ± 11	09:05	05:06	1, 12
6	JL Hurd	2020	USA	RCT	16	11/5	AD-MSC	No	11.4	Steroid	64.6 ± 9.6	57.6 ± 6.2	08:03	05:00	6, 12

AD: Adipose derived; BM: Bone marrow derived; MSC: Mesenchymal stem cell; PCS: Prospective controlled study; RCS: Retrospective comparative study; RCT: Randomized controlled trial; SD: Standard deviation; USA: United States of America.