Accuracy of early detection of colorectal tumours using stool methylation markers: A meta-analysis

Table 4 Weighted meta-regression on the diagnostic accuracy of the gene methylation assays

Covariate	Coefficient	SE	P value	RDOR	95%CI
QUADAS score1	-0.259	0.419	0.541	0.77	(0.33, 1.82)
Detection method2	0.101	0.377	0.790	1.11	(0.51, 2.40)
Blinded design3	-0.179	0.381	0.642	0.84	(0.38, 1.82)
Methylated genes4	0.302	0.394	0.449	1.35	(0.60, 3.03)

¹Based on QUADAS score, studies were divided into those with higher quality (QUADAS score ≥ 10) and those with lower quality (QUADAS score < 10);

²Detection method, which was divided into qualitative and quantitative assay methods;

³Blinded design: the study was included with or without blinded design;

⁴Methylated genes, which were divided into single gene and combination genes. QUADAS: Quality Assessment for Studies of Diagnostic Accuracy was used to assess the quality of primary studies of diagnostic accuracy; SE: Standard error; RDOR: Relative diagnostic odds ratio.