Accuracy of early detection of colorectal tumours using stool methylation markers: A meta-analysis

Table 3 Methylation of pooled genes for the diagnosis of colorectal adenomas

Wnt pathway	DNA damage repair pathway	Other pathways	SE (95%CI)	SP (95%CI)	DOR (95%CI)	AUC
Wnt pathway	DNA damage repair pathway	Other pathways	51% (47%-54%)	92% (90%-93%)	12.61 (8.66-18.37)	0.883
Wnt pathway	-	-	40% (35%-46%)	95% (92%-97%)	10.81 (6.43-18.16)	0.932
-	DNA damage repair pathway	-	21% (17%-27%)	95% (91%-97%)	4.23 (2.01-8.88)	0.672
-	-	Other pathways	32% (28%-35%)	94% (93%-95%)	7.78 (5.48-11.05)	0.873
SFRP2	-	-	43% (38%-49%)	94% (91%-97%)	11.06 (5.77-21.18)	0.956
-	MGMT	-	29% (22%-36%)	93% (87%-96%)	4.42 (2.18-8.95)	0.614
-	MLH	-	8% (4%-16%)	98% (92%-100%)	2.35 (0.14-40.83)	-
-	-	Vimentin	23% (17%-31%)	95% (92%-98%)	8.30 (2.60-26.55)	0.898
-	-	OSMR	25% (14%-39%)	95% (91%-98%)	5.20 (1.44-18.82)	0.817
-	-	P16	33% (23%-44%)	97% (89%-100%)	13.27 (3.40-51.83)	0.97
SFRP2	MLH	-	34% (29%-39%)	95% (92%-97%)	9.62 (4.64-19.93)	0.947
SFRP2	MGMT	-	38% (33%-42%)	94% (91%-96%)	7.85 (4.79-12.87)	0.753
SFRP2	-	OSMR	41% (35%-46%)	95% (92%-96%)	9.25 (5.13-16.69)	0.948
SFRP2	-	Vimentin	36% (32%-41%)	95% (93%-96%)	9.88 (5.55-17.57)	0.946
SFRP2	-	P16	41% (36%-46%)	95% (92%-97%)	10.37 (6.21-17.31)	0.948
SFRP2	MGMT	Vimentin	34% (30%-38%)	94% (92%-96%)	7.81 (4.96-12.29)	0.804
SFRP2	MGMT	OSMR	36% (32%-41%)	94% (92%-96%)	7.25 (4.61-11.39)	0.775
SFRP2	MGMT	P16	37% (33%-41%)	94% (92%-96%)	7.92 (5.14-12.21)	0.772
SFRP2	MLH	Vimentin	31% (27%-35%)	95% (93%-97%)	8.99 (4.95-16.31)	0.944
SFRP2	MLH	OSMR	33% (29%-38%)	95% (93%-97%)	8.37 (4.50-15.59)	0.941
SFRP2	MLH	P16	34% (30%-38%)	95% (93%-97%)	9.98 (5.45-18.27)	0.947

SE: Sensitivity; SP: Specificity; DOR: Diagnostic odds ratio; AUC: The area under the curve.