Relationship between apolipoprotein E gene polymorphism and total cholesterol level in patients with kidney diseases

Table 2 Meta-analysis of the association of apoE gene polymorphism with total cholecterol level

Genetic comparisons	Q test	P contrasts	Model seclected	Weighted mean differences (95%CI)	P value
E2E2 vs E3E3	1	-	Fixed	109.00 (-32.07-250.07)	0.13
E2E3 vs E3E3	13	< 0.00001	Random	-1.93 (-3.39--0.46)	0.01
E2E4 vs E3E3	3	0.48	Random	-2.48 (-4.23--0.72)	0.006
E3E4 vs E3E3	13	< 0.00001	Random	2.14 (0.46-3.83)	0.01
E4E4 vs E3E3	3	0.02	Random	0.30 (-4.25-4.84)	0.90
ε2 vs non-ε2	2	0.57	Fixed	-0.25 (-0.43--0.08)	0.005
ε4 vs non-ε4	4	0.0001	Random	0.20 (-1.42-1.83)	0.81
ε2 vs ε3	20	< 0.00001	Random	-1.23 (-1.99--0.46)	0.002
ε3 vs ε4	20	< 0.00001	Random	-0.79 (-1.50--0.08)	0.03
ε2 vs ε4	19	< 0.00001	Random	-2.77 (-4.05--1.49)	< 0.0001