Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B

Figure 2 Association between plasma soluble 4-1BB levels and hepatitis B virus markers as well as clinical parameters in treatment-naïve patients with chronic hepatitis B. A-C: The positive correlations of plasma soluble 4-1BB (HBsAg) levels with quantitative hepatitis B surface antigen (HBsAg), hepatitis B virus DNA, and hepatitis B e antigen (HBeAg); D-F: The correlations of plasma s4-1BB levels with alanine aminotransferase (ALT), IFNγ, and triglyceride (TG). Correlations were tested by Spearman’s rho (r), and the level of significance was expressed as the P value (P). CHB: Chronic hepatitis B.