Etomidate vs propofol in coronary heart disease patients undergoing major noncardiac surgery: A randomized clinical trial

Table 3 Comparison of hemodynamic parameters between groups

	Before anesthesia induction	3 min after anesthetic injection	Just after tracheal intubation	3 min after tracheal intubation	5 min after tracheal intubation
Heart rate (beats/min)
Propofol group	82.6 ± 9.1	58.9 ± 7.1	66.5 ± 9.7	63.2 ± 6.7	68.9 ± 8.8
Etomidate group	79.0 ± 7.3	71.3 ± 9.3	76.5 ± 6.9	71.3 ± 6.4	76.8 ± 5.2
P value	0.223	0.012	0.044	0.253	0.072
SBP (mmHg)
Propofol group	132.7 ± 12.4	89.4 ± 16.3	100.2 ± 13.1	93.1 ± 17.4	103.8 ± 13.2
Etomidate group	129.6 ± 17.2	100.3 ± 19.3	117.5 ± 12.9	112.3 ± 16.4	121.5 ± 15.3
P value	0.813	0.041	0.112	0.214	0.712
DBP (mmHg)
Propofol group	76.7 ± 18.7	62.9 ± 16.3	72.1 ± 16.7	68.6 ± 17.2	70.9 ± 18.4
Etomidate group	79.0 ± 16.1	73.0 ± 16.4	90.8 ± 20.2	91.2 ± 16.3	82.2 ± 15.4
P value	0.60	0.009	0.008	0.02	0.01
MAP (mmHg)
Propofol group	92.6 ± 18.7	68.9 ± 16.1	76.5 ± 16.5	86.2 ± 18.2	80.8 ± 18.2
Etomidate group	95.1 ± 17.2	80.2 ± 16.7	96.3 ± 22.5	93.5 ± 16.4	89.8 ± 15.5
P value	0.69	0.007	0.043	0.012	0.018

Data are presented as the mean ± SD (n = 40 in each group). DBP: Diastolic blood pressure; MAP: Mean arterial pressure; SBP: Systolic blood pressure.