Effect of alprostadil in the treatment of intensive care unit patients with acute renal injury

Table 2 Comparison of serum creatinine, blood urea nitrogen and kidney injury molecule-1 levels between the two groups (mean ± SD)

Group	n	Scr (μmol/L)		BUN (mmol/L)		KIM-1 (pg/mL)
		Before treatment	7 d after treatment	Before treatment	7 d after treatment	Before treatment	7 d after treatment
Alprostadil group	50	448.1 ± 95.2	180.6 ± 34.7ab	17.8 ± 3.9	8.1 ± 1.8ab	1338.2 ± 202.1	787.4 ± 144.2ab
Control group	50	420.8 ± 81.7	207.1 ± 42.4a	17.3 ± 3.4	9.3 ± 2.0a	1310.3 ± 231.8	855.8 ± 153.9a
T value		1.539	-3.420	0.683	-3.154	0.642	-2.293
P value		0.127	0.001	0.496	0.002	0.523	0.024
Group	n	NAGL (ng/mL)		IL-8 (ng/mL)
		Before treatment	7 d after treatment	Before treatment	7 d after treatment
Alprostadil group	50	126.9 ± 16.4	89.5 ± 11.0ab	58.3 ± 9.1	36.8 ± 7.0ab
Control group	50	130.0 ± 20.1	96.7 ± 12.4a	56.8 ± 8.3	41.0 ± 8.3a
T value		-0.845	-3.071	0.861	-2.735
P value		0.400	0.003	0.391	0.007

^aP < 0.05, compared with this group before treatment.

^bP < 0.05, compared with the control group. Scr: Serum creatinine; BUN: Blood urea nitrogen; KIM-1: Kidney injury molecule-1; NAGL: Neutrophil gelatinase-associated lipocalin; IL-8: Interleukin-8.