Heterochronic triple primary malignancies with Epstein-Barr virus infection and tumor protein 53 gene mutation: A case report and review of literature

Table 1 Summary of all existing cases of heterochronic triple primary malignancies in the English literature, n = 19

Ref.	Age in yr/gender	Sites	Tumor histology	Treatment	Outcome	Follow-up
Li et al[22], 2020	67/F	Uterine	Moderately differentiated endometrial cancer	Surgery RT CT ET	DFS	19 mo
		Colon	Ascending colon papillary adenocarcinoma and moderately differentiated tubular adenocarcinoma
		Breast	Invasive ductal carcinoma
Feng et al[23], 2018	66/M	Prostate	Acinar adenocarcinoma	Surgery CT	DFS	4 mo
		Colon	Moderately differentiated adenocarcinoma
		Lung	Moderately differentiated adenocarcinoma
Gheonea et al[24], 2017	75/M	Prostate	Prostate carcinoma	ET	NM	NM
		Lung	Small lung cell carcinoma
		Skin	Basal cell carcinoma
Kim et al[25], 2017	73/M	Lung	Small cell carcinoma	Surgery CT	DFS	44 mo
			Poorly differentiated adenocarcinoma
			Moderately differentiated squamous cell carcinoma
Yoshikawa et al[26], 2017	60/M	Bile duct	Papillary adenocarcinoma	Surgery CT RT	DFS	NM
			Poorly differentiated cholangio cellular carcinoma
			A well-differentiated hilar cholangiocarcinoma
Pastore et al[27], 2015	70/M	Renal	Renal clear cell carcinoma	Surgery RT CT ET	NM	NM
		Oropharynx	Poorly-differentiated (G3) squamous cell carcinoma
		Prostate	Adenocarcinoma
Nishikawa et al[28], 2014	37/M	Hypopharynx	Squamous cell carcinoma	Surgery RT CT	DOD	10 yr
		Esophagus
		Tongue
Okumura et al[29], 2013	73/M	Prostatic	Moderately differentiated adenocarcinoma	NM	NM	NM
		Bladder	Grade 2 urothelial carcinoma
		Renal	Grade 2 clear renal cell carcinoma
Zargar-Shoshtari et al[30], 2013	71/M	Renal	Clear renal cell carcinoma	Surgery ET	DOD	1 yr
		Prostate	Adenocarcinoma
		Breast	Poorly differentiated invasive ductal cell carcinoma
Freeman[31], 2013	72/M	Colon	Moderately differentiated adenocarcinoma in the distal sigmoid colon	Surgery	DFS	15 yr
			Infiltrative moderately differentiated colonic
			Adenocarcinoma in the descending colon moderately differentiated adenocarcinoma in the rectum
Chang et al[32], 2013	67/M	Maxillary sinus	Adenoid cystic carcinoma	Surgery RT	DFS	15 yr
		Esophagus	Squamous cell carcinoma			22 mo
		Tympanic membrane				18 mo
Egashira et al[33], 2013	63/F	Esophagus	Esophageal cancer	Surgery	DFS	10 mo
		Colon	Ascending colon cancer
		Jejunum	Jejunal cancer
Takalkar et al[34], 2013	64/F	Small intestine	Moderately differentiated adenocarcinoma	Surgery CT	NM	NM
		Breast	Well differentiated infiltrated duct carcinoma
		Ovary	Papillary adenocarcinoma
Arikan-Sengul et al[35], 2009	70/M	Bladder	Transitional cell carcinoma	NM	NM	NM
		Prostate
		Renal	Renal cell carcinoma
Yamanaka et al[36], 2008	24/F	Humerus	Steosarcoma	Surgery CT	NM	NM
		Breast	The light breast cancer the left breast cancer
Oztop et al[37], 2008	76/M	Rectum	Metastatic rectal cancer	Surgery CT RT ET	DOD	1 yr
		Prostate	Prostate cancer
		Lymphocyte	Philadelphia (+) chronic myeloid leukemia
Baba et al[38], 2002	64/M	Lung	Small cell lung cancer	Surgery	DFS	20 mo
		Prostate	Moderately or poorly differentiated adenocarcinoma
		Breast	Scirrhous carcinoma
Iioka et al[39], 2000	60/M	Colon	Sigmoid colon cancer	Surgery RT	DOD	13 mo
		Stomach	Early gastric cancer
		Esophagus	The middle thoracic esophagus cancer
Saitoh et al[40], 1995	64/M	Lung	Moderately differentiated squamous cell carcinoma	Surgery RT	NM	NM
		Colon	The rectum carcinoma
		Trachea	Moderately differentiated squamous cell carcinoma with mediastinal lymph node metastasis

CT: Computed tomography; DFS: Disease free; DOD: Died of disease; ET: Endocrinotherapy; F: Female; M: Male; NED: No evidence of disease; NM: Not mentioned; RT: Radiotherapy.