Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report

Figure 5 Frozen autografting of osteosarcoma and postoperative X-rays. A: In the surgery, tumor bone was exposed with wide margins and a proximal tibial osteotomy was performed 3 cm below the knee joint; B: The tibia was rotated and put in the container filled with liquid nitrogen for 20 min; C: Thawed at room temperature for 15 min and in distilled water for 15 min; D: Post-operative X-ray. Frozen autograft was replaced with a small intramedullary nail, plate, and polymethylmethacrylate. Arrow is osteotomy line; E: Three years after surgery, an X-ray revealed fracture of the frozen bone at the end plate and additional plate fixation with autologous bone grafting was performed; F: 13 years post-operatively. Although multiple surgeries were needed for non-union and infection, limb salvage was successful and no recurrences have been detected.