Serum magnesium level as a predictor of acute kidney injury in patients with acute pancreatitis

Table 1 Baseline characteristics

	Mg2+ (mg/dL)		P value	AKI, n = 85	Non-AKI, n = 148	P value
	< 0.755 mg/dL, n = 87	≥ 0.755 mg/dL, n = 146
Age, yr	39 (32, 52)	44 (34, 58)	0.063	38 (30, 50)	44.5 (35.5, 54.5)	0.011
Gender, male, n (%)	59 (67.8)	98 (67.1)	0.913	59 (69.4)	98 (66.2)	0.913
BMI	27.1 (24.7, 30.1)	25.6 (23.9, 28.1)	0.028	27.6 (24.8, 30.7)	25.4 (23.4, 27.7)	< 0.001
APACHE II	9 (7, 12)	7 (5, 9)	0.002	11 (8, 14)	7 (4, 9)	< 0.001
SOFA	3 (3, 4)	3 (2, 4)	0.075	4 (3, 5)	3 (2, 4)	< 0.001
CTSI	6 (3, 6)	5 (3, 6)	0.122	6 (6, 6)	4 (2, 6)	< 0.001
Severity classification, n (%)			0.064			< 0.001
MAP	21 (24.1)	50 (34.2)		7 (8.2)	64 (43.2)
MSAP	47 (54.0)	79 (54.1)		45 (53.0)	81 (54.7)
SAP	19 (21.8)	17 (11.6)		33 (38.8)	3 (2.1)
Comorbidities
Diabetes	23 (26.4)	24 (16.4)	0.066	20 (23.5)	27 (18.2)	0.066
Hypertension	22 (25.3)	36 (24.7)	0.914	22 (25.9)	36 (24.3)	0.914
Hyperlipidemia	25 (28.7)	36 (24.7)	0.493	21 (24.7)	40 (27.0)	0.493
Laboratory data
WBC	13.4 (10.6, 16.6)	12.8 (10.1, 15.7)	0.336	12.9 (10.9, 16.6)	12.9 (10.3, 16.1)	0.685
Ly%	8.1 (5.1, 11.2)	6.7 (4.7, 10.6)	0.297	6.9 (4.9, 10.5)	7.2 (5, 11.2)	0.769
IL-6	199.6 (104.8, 366.4)	115.4 (45.4, 201.5)	< 0.001	222.8 (130.4, 370)	104.8 (45.4, 178.4)	< 0.001
PCT	1.2 (0.4, 3.3)	0.4 (0.1, 1.6)	< 0.001	2.1 (1.1, 7.7)	0.3 (0.1, 0.8)	< 0.001
Platelets	193 (142, 238)	174 (134, 224)	0.215	199 (132, 236)	176.5 (142, 218)	0.248
BUN	5.4 (3.7, 6.3)	5.1 (4, 6.9)	0.576	6 (4, 8.3)	4.8 (3.8, 5.9)	< 0.001
Creatinine	61 (49, 8)	63 (53, 8)	0.924	50 (41, 57.3)	51 (46, 59)	0.184
HCO3-	18.9 (15.1, 23.5)	22 (18.7, 24.2)	< 0.001	17.8 (13.7, 21.3)	22.6 (19.8, 24.7)	< 0.001
Cl-	103 (99, 105)	102 (100, 105)	0.825	103.7 (101, 107)	102 (99, 104)	< 0.001
Mg2-				0.7 (0.6, 0.7)	0.885 (0.8, 0.9)	< 0.001

Mg²⁺: Magnesium; BMI: Body mass index; AKI: Acute kidney injury; SOFA: Sequential organ failure assessment; CTSI: CT severity index; MAP: Mild acute pancreatitis; MSAP: Mild severe acute pancreatitis; SAP: Severe acute pancreatitis; WBC: White blood cells; Ly%: Lymphocytes%; IL-6: Interleukin-6; PCT: Procalcitonin; BUN: Blood urea nitrogen.