Regulating monocyte infiltration and differentiation: Providing new therapies for colorectal cancer patients with COVID-19

Figure 4 Coronavirus disease 2019 infection promotes the activation of NF-κB and CCR5 signaling pathways in monocytes. The limma R package was used to identify differentially expressed pathways (DEGeneset) in severe and nonsevere Coronavirus disease 2019 (COVID-19) patients, and healthy controls with an absolute value score > 0.35 and a false discovery rate < 0.001. Nine differential pathways were found. COVID-19 infection promoted the activation of NF-κB and CCR5 signaling pathways in monocytes. Multiple metabolic pathways were also involved.