Regulating monocyte infiltration and differentiation: Providing new therapies for colorectal cancer patients with COVID-19

Figure 3 Impact of coronavirus disease 2019 on monocytes. A: Coronavirus disease 2019 (COVID-19) induces the differentiation of M1 and M2 macrophages by affecting cytokines, especially TGF-β1 and TNF-α; B: COVID-19 patients had higher macrophage infiltration than healthy people. In severe COVID-19, the M1/M2 ratio increased. GM-CSF: Granulocyte-macrophage colony-stimulating factor; IFN-γ: Interferon-γ; IL: Interleukin; M1: Type 1 macrophage; M2: Type 2 macrophage.