Endoscopic ultrasound fine needle aspiration vs fine needle biopsy in solid lesions: A multi-center analysis

Table 2 Summary of diagnostic results

	Total	FNA	FNB	P value
All Lesions
Sensitivity	81.02% (95%CI 78.27 to 83.56)	74.53% (95%CI 69.37 to 79.23)	84.70% (95%CI 81.45 to 87.57)	< 0.001
Specificity	97.92% (95%CI 95.54 to 99.23)	96.62% (95%CI 92.29 to 98.89)	99.29% (95%CI 96.11 to 99.98)	< 0.001
Positive likelihood ratio	39.03 (95%CI 17.67 to 86.20)	22.06 (95%CI 9.30 to 52.34)	119.42 (95%CI 16.93 to 842.21)	< 0.001
Negative likelihood ratio	0.19 (95%CI 0.17 to 0.22)	0.26 (95%CI 0.22 to 0.32)	0.15 (95%CI 0.13 to 0.19)	0.676
Positive predictive value	99.17% (95%CI 98.18 to 99.62)	97.93% (95%CI 95.23 to 99.12)	99.79% (95%CI 98.54 to 99.97)	< 0.001
Negative predictive value	62.89% (95%CI 59.63 to 66.04)	63.84% (95%CI 59.34 to 68.11)	61.95% (95%CI 57.26 to 66.43)	0.459
Accuracy	85.20% (95%CI 83.03 to 87.19)	81.55% (95%CI 77.72 to 84.96)	87.62% (95%CI 84.96 to 89.97)	0.004
Serious adverse events	2 (0.17)	1 (0.21)	1 (0.14)	0.775
Pancreatic lesions
Sensitivity	87.96% (95%CI 84.74 to 90.71)	85.62% (95%CI 79.22 to 90.66)	89.09% (95%CI 85.22 to 92.24)	0.229
Specificity	97.59% (95%CI 91.57 to 99.71)	96.88% (95%CI 83.78 to 99.92)	98.04% (95%CI 89.55 to 99.95)	0.387
Positive likelihood ratio	36.50 (95%CI 9.28 to 143.58)	27.40 (95%CI 3.98 to 188.81)	45.44 (95%CI 6.52 to 316.51)	0.714
Negative likelihood ratio	0.12 (95%CI 0.10 to 0.16)	0.15 (95%CI 0.10 to 0.22)	0.11 (95%CI 0.08 to 0.15)	0.253
Positive predictive value	99.54% (95%CI 98.21 to 99.88)	99.28% (95%CI 95.21 to 99.89)	99.66% (95%CI 97.69 to 99.95)	0.529
Negative predictive value	57.86% (95%CI 51.88 to 63.61)	57.41% (95%CI 47.88 to 66.41)	58.14% (95%CI 50.44 to 65.46)	0.867
Accuracy	89.35% (95%CI 86.54 to 91.76)	87.50% (95%CI 81.97 to 91.82)	90.29% (95%CI 86.86 to 93.07)	0.307
Serious adverse events	1 (0.17)	0 (0.00)	1 (0.26)	0.821
Non-pancreatic lesions
Sensitivity	72.31% (95%CI 67.58 to 76.69)	63.29% (95%CI 55.27 to 70.81)	78.45% (95%CI 72.59 to 83.56)	< 0.001
Specificity	98.07% (95%CI 95.13 to 99.47)	96.52% (95%CI 91.33 to 99.04)	100.00% (95%CI 96.07 to 100.00)	< 0.001
Positive likelihood ratio	37.42 (95%CI 14.15 to 98.95)	18.20 (95%CI 6.90 to 48.01)	NA	NA
Negative likelihood ratio	0.28 (95%CI 0.24 to 0.33)	0.38 (95%CI 0.31 to 0.47)	0.22 (95%CI 0.17 to 0.28)	0.719
Positive predictive value	98.60% (95%CI 96.38 to 99.47)	96.15% (95%CI 90.45 to 98.51)	100.00%	< 0.001
Negative predictive value	65.27% (95%CI 61.53 to 68.84)	65.68% (95%CI 60.86 to 70.20)	64.79% (95%CI 59.01 to 70.17)	0.820
Accuracy	81.24% (95%CI 77.87 to 84.29)	77.29% (95%CI 71.85 to 82.12)	84.57% (95%CI 80.17 to 88.32)	0.023
Serious adverse events	1 (0.16)	1 (0.87)	0 (0.00)	0.321

FNA: Fine needle aspiration; FNB: Fine needle biopsy; ROSE: Rapid on-site evaluation.