Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation, normal T-cell expressed and secreted

Table 2 Ileal regulated on activation, normal T-cell expressed and secreted, tumor necrosis factor α, interleukin 1β, and interleukin 6 levels in rats of different groups

Group	RANTES (g/mL)	TNF-α (pg/mL)	IL-1β (pg/mL)	IL-6 (pg/mL)
Control (n = 11)	3.40 ± 1.45	347.04 ± 60.66	240.4 ± 37.08	195.11 ± 28.60
Model (n = 9)	29.29 ± 4.07a	1015.73 ± 90.96a	453.52 ± 54.82a	436.01 ± 46.29
LM (n = 9)	22.47 ± 3.72a,b	720.82 ± 88.16b	330.89 ± 49.06a,b	337.66 ± 73.79b
MM (n = 10)	17.39 ± 2.59a,b,c	487.48 ± 115.29a,b	301.43 ± 44.51a,b	271.25 ± 36.82b,c
HM (n = 10)	14.10 ± 1.59a,b,c,d	428.79 ± 48.71a,b,c	294.27 ± 68.2a,b	237.75 ± 16.05b,c,d

The expression levels of regulated on activation, normal T-cell expressed and secreted and cytokines in ileal tissue of septic rats after magnolol intervention were determined using Western blot assay. All data are represented as the mean ± SD.

^aP < 0.01 vs Control group.

^bP < 0.05 vs Model group.

^cP < 0.05 vs LM group.

^dP < 0.05 vs MM group.

TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β; IL-6: Interleukin-6; RANTES: Regulated on activation, normal T-cell expressed and secreted; Control: The Control group; Model: Severe sepsis group; LM: Low-dose magnolol group; MM: Middle-dose magnolol group; HM: High-dose magnolol group.