Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation, normal T-cell expressed and secreted

Table 1 Serum regulated on activation, normal T-cell expressed and secreted, tumor necrosis factor α, interleukin 1β, and interleukin 6 levels in rats of different groups

Group	RANTES (ng/mL)	TNF-α (pg/mL)	IL-1β (pg/mL)	IL-6 (pg/mL)
Control (n = 11)	0.65 ± 0.25	124.91 ± 11.29	185.87 ± 24.97	183.69 ± 43.02
Model (n = 9)	5.17 ± 0.70a	256.89 ± 19.55a	383.01 ± 41.85a	380.99 ± 44.11a
LM (n = 9)	4.07 ± 0.67a,b	167.39 ± 20.92a,b	318.83 ± 74.06a,b	308.21 ± 73.22a,b
MM (n = 10)	3.13 ± 0.45a,b,c	143.87 ± 15.22a,b,c	256.79 ± 25.37a,b,c	246.14 ± 41.73a,b,c
HM (n = 10)	2.52 ± 0.28a,b,c,d	144.49 ± 18.02a,b,c	225.07 ± 17.46a,b,c,d	215.18 ± 12.49a,b,c,d

The contents of regulated on activation, normal T-cell expressed and secreted and cytokines in serum of septic rats after magnolol intervention were determined using enzyme-linked immunosorbent assay. All data are represented as the mean ± SD.

^aP < 0.01 vs Control group.

^bP < 0.05 vs Model group.

^cP < 0.05 vs LM group.

^dP < 0.05 vs MM group.

TNF-α: Tumor necrosis factor-α; IL-1β: Interleukin-1β; IL-6: Interleukin-6; RANTES: Regulated on activation, normal T-cell expressed and secreted; Control: The Control group; Model: Severe sepsis group; LM: Low-dose magnolol group; MM: Middle-dose magnolol group; HM: High-dose magnolol group.