Role of circular RNAs in gastrointestinal tumors and drug resistance

Table 5 circRNAs involved in pancreatic cancer gene transcription regulation and drug resistance

Cancer type	circRNA	Gene expression		Mechanism	Drug	Ref.
		Up	Down
Pancreatic cancer	circBFAR	↑		Acts as a miR-34b-5p sponge	NR	[119]
Pancreatic cancer	circFOXK2	↑		Acts as miR-942 sponge	NR	[120]
Pancreatic cancer	circ-ADAM9	↑		Activate ERK/VEGF signaling pathway through miR-217	NR	[121]
Pancreatic cancer	circ-ASH2L	↑		Acts as a sponge for miR-34a	NR	[122]
Pancreatic cancer	circ-LDLRAD3	↑		Adjustable via miR-137-3p/PTN axis	NR	[123]
Pancreatic cancer	circ-0000977	↑		Acts as a sponge for miR-153	NR	[124]
Pancreatic cancer	hsa-circRNA-0007334	↑		Competitive binding through hsa-miR-144-3p	NR	[125]
pancreatic cancer	ciRS-7	↑		Acts as miR-7 sponge	NR	[126]
Pancreatic cancer	circ-0030235	↑		Acts as miR-1253 and miR-1294 sponge	NR	[127]
Pancreatic cancer	circZMYM2	↑		Acts as a miR-335-5p sponge	NR	[128]
Pancreatic cancer	circ-0007534	↑		Acts as miR-625, miR-892b sponge	NR	[129]
Pancreatic cancer	circ-IARS	↑		Acts as miR-122 sponge	NR	[130]
Pancreatic cancer	circ-PDE8A	↑		As a sponge of miR-338 to regulate MACC1	NR	[131]
Pancreatic cancer	circHIPK3	↑		Acts as a miR-330-5p sponge	Gemcitabine	[133]

NR: Not reported; circRNA: Circular RNA.