Role of circular RNAs in gastrointestinal tumors and drug resistance

Table 4 circRNAs involved in esophageal cancer gene transcription regulation and drug resistance

Cancer type	circRNA	Gene expression		Mechanism	Drug	Ref.
		Up	Down
Esophageal cancer	circUBAP2	↑		Acts as miR-422a sponge	NR	[108]
Esophageal cancer	hsa-circ-0006948	↑		miR-490-3p to enhance HMGA2-induced EMT	NR	[109]
Esophageal cancer	circ-0000654	↑		miR-149-5p/IL-6/STAT3 pathway	NR	[110]
Esophageal cancer	circGSK3	↑		β-catenin signal passing	NR	[111]
Esophageal cancer	circ-Foxo3		↓	miR-23a/PTEN pathway	NR	[112]
Esophageal cancer	circPVT1	↑		Acts as miR-4663 sponge	NR	[113]
Esophageal cancer	ciRS-7	↑		Acts as a miR-876-5p sponge	Rapamycin	[114,115]
Esophageal cancer	circRNA-001275	↑		Acts as a miR-370-3p sponge	Cisplatin	[117]

NR: Not reported; circRNA: Circular RNA.