Role of circular RNAs in gastrointestinal tumors and drug resistance

Table 1 circRNAs involved in gastric cancer gene transcription regulation and drug resistance

Cancer species	circRNA	Gene expression		Mechanism	Drug	Ref.
		Up	Down
Gastric cancer	circRNA100876	↑		Via miR-665/YAP1 signaling pathway	NR	[66]
Gastric cancer	circCUL3	↑		Acts as a sponge for miR-515-5p	NR	[67]
Gastric cancer	circTMEM87A	↑		Acts as a sponge for miR-142-5p	NR	[68]
Gastric cancer	circRNA0044516	↑		Acts as a sponge for miR-149	NR	[69]
Gastric cancer	circ0000039	↑		Acts as a sponge for miR-1292-5p	NR	[70]
Gastric cancer	has-circ-0004872		↓	Acts as a sponge for miR-224	NR	[71]
Gastric cancer	circ-ITCH		↓	Negative regulation of Wnt/β-catenin signaling pathway	NR	[72]
Gastric cancer	circPDZD8	↑		Acts as a sponge for miR-197-5p	NR	[73]
Gastric cancer	circMTHFD2	↑		Combined with miR-124 to exert sponge effect and induce MDR-1 protein	Pemetrexed	[74]
Gastric cancer	circ-PVT1	↑		By negatively regulating miR-124-3p	Paclitaxel	[75]
Gastric cancer	circAKT3	↑		Promote PIK3R1 expression through miR-198	Cisplatin	[76]
Gastric cancer	circFhashsa-circ-0058147	↑		Regulation of cisplatin activity via miR-182-5p	Cisplatin	[77]

NR: Not reported; circRNA: Circular RNA.