Is endoscopic retrograde appendicitis therapy a better modality for acute uncomplicated appendicitis? A systematic review and meta-analysis

Table 1 Detailed characteristics of included studies in this meta analysis

Ref.	Studies types	Patients age	Treatment		Sample size		Disease	Outcomes
			Experiment	Control	Experiment	Control
Kang et al[20], 2020	RCT	1 to 13 years old	Modified ERAT	Antibiotics treatment	36	47	Acute uncomplicated appendicitis in children	Length of hospital stay
Deng et al[21], 2018	RCT	18-62 years old	ERAT	Laparoscopic appendectomy	20	20	Acute appendicitis	Duration of operation, Bed rest time; time interval of body temperature returning to normal range; time interval of white blood cells count returning to normal time range, complication
Huang et al[22], 2020	RCT	18-65 years old	ERAT	Laparoscopic appendectomy	78	119	Acute appendicitis	Duration of operation, bed rest time, complication
Lin et al[23], 2016	RCT	18-70 years old	ERAT	Laparoscopic appendectomy/antibiotics treatment	44	45/36	Simple appendicitis	Length of hospital stay, bed rest time, time interval of body temperature returning to normal range, inflammatory factors, complication
Ma et al[24], 2020	RCT	19-74 years old	ERAT	Laparoscopic appendectomy	20	20	Non-complex appendicitis	Duration of operation, length of hospital stay, time interval of body temperature returning to normal range, inflammatory factors, complication
Wang et al[25], 2017	RCT	3 to 13 years old	ERAT	Laparoscopic appendectomy	42	42	Acute uncomplicated appendicitis in children	Duration of operation, length of hospital stay, bed rest time, time interval of body temperature returning to normal range, complication
Pan et al[26], 2018	RCT	19-62 years old	ERAT	Laparoscopic appendectomy	35	36	Acute appendicitis	Duration of operation, length of hospital stay, bed rest time, inflammatory factors
Shen et al[27], 2020	Case-control	NA	ERAT combined with antibiotics treatment	Antibiotics treatment	42	57	Acute appendicitis	Length of hospital stay
Ye et al[28], 2016	RCT	18-70 years old	ERAT	Laparoscopic appendectomy	57	57	Non-perforated acute appendicitis	Length of hospital stay, bed rest time, inflammatory factors, complication
Zhu et al[29], 2018	RCT	NA	ERAT	Antibiotics treatment	17	24	Atypical acute appendicitis	Complication
Yang et al[30], 2016	RCT	20-60 years old	ERAT	Laparoscopic appendectomy	35	35	Acute uncomplicated appendicitis	Duration of operation, bed rest time, length of hospital stay, time interval of body temperature returning to normal range
Li et al[31], 2016	Case-control	14-73 years old	ERAT	Laparoscopic appendectomy	21	20	Uncomplicated acute appendicitis	Duration of operation, length of hospital stay, bed rest time, time interval of body temperature returning to normal range, time interval of white blood cells count returning to normal time range, complication

ERAT: Endoscopic retrograde appendicitis therapy.