Clinicopathological features of small T1 colorectal cancers

Table 3 Comparison of clinicopathological characteristics between < 10 mm and ≥ 10 mm tumors in surgical resection cohort T1 colorectal cancers (n = 798)

	< 10 mm (n = 73)	≥ 10 mm (n = 725)	P value
Age, yr	66.0 ± 11.8	65.5 ± 11.2	0.71
Sex (male/female)	55 (75.3)/18 (24.7)	438 (60.4)/287 (39.6)	0.01
Location (left-sided/right-sided)	51 (69.9)/22 (30.1)	516 (71.2)/209 (28.8)	1.00
Tumor size (mm)	7.6 ± 1.1	22.3 ± 12.0	< 0.01
Polypoid/non-polypoid growth (polypoid/non-polypoid)	26 (35.6)/47 (64.4)	473 (65.2)/252 (34.8)	< 0.01
Adenoma component (±)	15 (20.5)/58 (79.5)	236 (32.6)/489 (67.4)	0.04
Morphology (flat/ protruded/ depressed)	4 (5.5)/ 24 (32.9)/ 45 (61.6)	307 (42.3)/214 (29.5)/204 (28.1)	0.03
Initial treatment (endoscopic/surgical)	43 (58.9)/30 (41.1)	316 (43.6)/409 (56.4)	0.01
Depth of invasion (T1b/T1a)	67 (91.8)/6 (8.2)	631 (87.0)/94 (13.0)	0.35
Histological grade (Por or Muc1/tub1 or tub2)	3 (4.1)/70 (95.9)	47 (6.5)/678 (93.5)	0.61
Vascular invasion (±)	32 (43.8)/41 (56.2)	261 (36.0)/464 (64.0)	0.20
Lymphatic invasion (±)	34 (46.6)/39 (53.4)	270 (37.2)/455 (62.8)	0.13
Tumor budding (BD 2 or 3/BD 1)	21 (28.8)/52 (71.2)	193 (26.6)/532 (73.4)	0.68
Lymph node metastasis (±)	9 (12.3)/64 (87.7)	79 (10.9)/ 646 (89.1)	0.70

¹Por or Muc, poorly differentiated adenocarcinoma or mucinous carcinoma. Results are expressed as mean ± SD or number of patients (%), as appropriate.