Clinicopathological features of small T1 colorectal cancers

Table 2 Comparison of clinicopathological characteristics between < 10 mm and ≥ 10 mm tumors in total cohort T1 colorectal cancers (n = 1152)

	< 10 mm (n = 116)	≥ 10 mm (n = 1036)	P value
Age, yr	66.8 ± 11.5	66.4 ± 11.6	0.72
Sex (male/female)	84 (72.4)/32 (27.6)	645 (62.3)/391 (37.7)	0.03
Location (left-sided/right-sided)	77 (66.4)/39 (33.6)	710 (68.5)/326 (31.5)	0.67
Tumor size (mm)	7.5 ± 1.2	22.5 ± 12.6	0.08
Polypoid/non-polypoid growth (polypoid/non-polypoid)	50 (43.1)/66 (56.9)	664 (64.1)/372 (35.9)	< 0.01
Adenomatous component (±)	34 (29.3)/82 (70.7)	432 (41.7)/604 (58.3)	< 0.01
Morphology(flat/ protruded/ depressed)	10 (8.6)/46 (39.7)/60 (51.7)	387 (37.4)/429 (41.4)/220 (21.2)	< 0.01
Initial treatment (endoscopic/surgical)	86 (74.1)/30 (25.9)	624 (60.2)/412 (39.8)	< 0.01
Surgical resection1	73 (62.9)/43 (37.1)	725 (70.0)/311 (30.0)	0.14
Depth of invasion (T1b/T1a)	72 (62.1)/44 (37.9)	754 (72.8)/282 (27.2)	0.02
Histological grade (Por or Muc2/tub1 or tub2)	3 (2.6)/113 (97.4)	55 (5.3)/981 (94.7)	0.26
Vascular invasion (±)	35 (30.2)/81 (69.8)	287 (27.7)/749 (72.3)	0.59
Lymphatic invasion (±)	38 (32.8)/78 (67.2)	304 (29.3)/732 (70.7)	0.45
Tumor budding (BD 2 or 3/BD 1)	24 (20.7)/92 (79.3)	218 (21.0)/818 (79.0)	1.00

¹Surgical resection: initial and additional surgical resection.

²Por or Muc, poorly differentiated adenocarcinoma or mucinous carcinoma. Results are expressed as mean ± SD or number of patients (%), as appropriate.