Utility of cooling patches to prevent hand-foot syndrome caused by pegylated liposomal doxorubicin in breast cancer patients

Table 9 Comparison of different cooling methods and the incidence of hand-foot syndrome

n	Tumor	Chemotherapy regimen	Dosage of PLD	Cold therapy equipment	Cooling parts of the body	Cooling time	Incidence of HFS	Ref.
20	Ovarian cancer	Monotherapy	30-50 mg/m2	Ice packs	Around the wrists and ankles	After chemotherapy for 24 h	1/17 (5.9%)	Molpus et al[12]
53	Ovarian cancer	Combination or monotherapy	30-50 mg/m2	Ice packs	Around the wrists and ankles	During chemotherapy infusion	2/28 (7.1%)	Mangili et al[13]
55	Ovarian cancer	Combination	30 mg/m2	FGS	Whole hands and feet	From 15 min before infusion to 15 min after infusion	≥ Grade 2 (31.70%)	Bun et al[14]
41		Monotherapy	50 mg/m2				≥ Grade 2 (5.5%)
51	Breast cancer	Combination	30-35 mg/m2	The cooling patches	Palm and back of hands	Start 15 min before infusion and lasted for 10 h	1/51 (2.0%)	Our study

PLD: Pegylated liposomal doxorubicin.