High-resolution computed tomography findings independently predict epidermal growth factor receptor mutation status in ground-glass nodular lung adenocarcinoma

Figure 2 Receiver operating characteristic curves. A: Receiver operating characteristic curves for assessing the predictive values of nodule size (red). For pure ground-glass nodular adenocarcinomas with epidermal growth factor receptor (EGFR) mutations, the optimal cut-off value was 8.65 mm; the model yielded a sensitivity of 100%, a specificity of 57.1%, and an AUC of 0.782 (95%CI: 0.609–0.956; P = 0.028); B: Nodule size (red) and nodule size in combination with vacuole/honeycomb sign (blue) in ground-glass nodular adenocarcinomas (mixed) with EGFR mutations. The optimal cutoff value was set to 13.38 mm; the sensitivity, specificity and AUC were 74.2%, 50.7%, and 0.625 (95%CI: 0.504-0.745; P = 0.048), respectively. The final model showed an AUC of 0.698 (95%CI: 0.589-0.806; P = 0.002). Its sensitivity was 83.9% and specificity was 52.2%.