High-resolution computed tomography findings independently predict epidermal growth factor receptor mutation status in ground-glass nodular lung adenocarcinoma

Table 2 High-resolution computerized tomography signs

HRCT findings	Mutant EGFR group (n = 31)	Wild-type group (n = 67)	P value
Nodule size (mm)	17.19 ± 6.79	14.37 ± 6.30	0.047a
Pure GGNs
Nodule size (mm)	12.79 ± 5.24	9.24 ± 3.26	0.042a
Partial solid nodules
Nodule size (mm)	18.63 ± 6.47	16.68 ± 6.05	0.216
Proportion of ground-glass component (%)	56.10 ± 24.01	51.05 ± 28.13	0.457
Nodule morphology			0.137
Round-like/ovoid	14 (45.2%)	41 (61.2%)
Irregular	17 (54.8%)	26 (38.8%)
Spicules on the edge of the nodule	20 (64.5%)	34 (50.7%)	0.202
Lobules on the border of the nodule	29 (93.5%)	61 (91.0%)	1.000
Vacuole/honeycomb sign	25 (80.6%)	36 (53.7%)	0.011a
Pleural indentation	20 (64.5%)	33 (49.3%)	0.159
Relationship with bronchus/bronchovascular bundles			0.613
Bronchus truncated in the nodule	1 (3.2%)	6 (9.0%)
Bronchus continuous in the nodule, with dilation or twisted appearance	11 (35.5%)	20 (29.9%)
Bronchus continuous in the nodule, without dilation or twisted appearance	7 (22.6%)	11 (16.4%)
Bronchus not associated with ground-glass shadows	12 (38.7%)	30 (44.8%)
Relationship with blood vessels			0.488
Blood vessels closely packed around the nodule with adherent-like pattern	0 (0.0%)	3 (4.5%)
Blood vessels closely packed within the nodule	20 (64.5%)	41 (61.2%)
Vascular clustering around the nodule	11 (35.5%)	23 (34.3%)

^aP < 0.05 is statistically significant.

HRCT: high-resolution computerized tomography; EGFR: Epidermal growth factor receptor; GGN: ground-glass nodule.