Emerging role of long noncoding RNAs in recurrent hepatocellular carcinoma

Table 1 Recurrent hepatocellular carcinoma associated long non-coding RNAs

Gene	Gene ID	Location	Expression	miRNA	Processes	Clinical association	Ref.
PTTG3P	26255	8q13.1	↑	miR-383	Proliferation, migration, invasion, metastasis, cell apoptosis, cell cycle progression, tumorigenesis, EMT	Tumor size, TNM stage, poor prognosis, metastasis	[40,41]
PDIA3P1	171423	1q21.1	↑	miR-125a/b, miR-124	Proliferation, migration, invasion	Tumor size, metastasis, TNM stage, poor RFS and OS	[43,67]
MALAT1	378938	11q13.1	↑	miR-146a, miR-22, miR-3064-5p, miR-125a-3p, miR-140, miR-124-3p, miR-124, miR-30a-5p, miR-195	Proliferation, apoptosis, autophagy, proliferation, migration, invasion, angiogenesis, immunosuppression, glucose metabolism	Poor RFS and OS, metastasis	[68-79]
UCA1	652995	19p13.12	↑	miRNA-193a-3p, miR-18a, miR-124, miR-203, miR-216B	Proliferation, migration, invasion, apoptosis, EMT	TNM stage, intrahepatic metastasis, postoperative recurrence, postoperative survival, shorter OS, tumor size, vascular invasion	[49,50,80-84]
MEG3	55384	14q32.2	↓	miR-9-5p, miR-10a-5p, miR-493-5p, miR-483-3p, miR-26a, miR-29a	Cell apoptosis, growth inhibition, proliferation, apoptosis, cell cycle progression, migration, invasion, EMT	Poor RFS and OS, metastasis,	[55-58,61]
GAS5	60674	1q25.1	↓	miR-21, miR-1323, miR-182, miR-135B	Proliferation, invasion, apoptosis, metastasis	Drug resistance, metastasis, shorter RFS, poor prognosis, TNM stage, differentiation, glucose levels, portal vein tumor thrombosis, tumor size, lymph node metastasis	[63,65,66,85-88]
CASC2	255082	10q26.11	↓	miR-183, miR-362-5p, miR-24-3p, miR-367	Proliferation, migration, invasion, colony formation, cell cycle, apoptosis, metastasis, EMT	Tumor size, metastasis	[89-94]
H19	283120	11p15.5	↑	miR675, miR-193B, miR-15b, miR-675, miR-326	Proliferation, motility, migration, invasion, apoptosis, EMT	Differentiation, drug resistance, metastasis, growth, shorter survival time, lymph node metastasis, distant metastasis	[32,95-103]

EMT: Epithelial-mesenchymal transition; RFS: Recurrence-free survival; OS: Overall survival.