Validation of diagnostic strategies of autoimmune atrophic gastritis: A case report

Table 1 Comparison of AAG with Helicobacter pylori-induced atrophic gastritis

	AAG	Helicobacter pylori-induced atrophic gastritis
Serological tests
APCAs, AIFAs	Positive	Negative
PG I levels	Low	Normal
The PG I/PG II ratio	Low	Normal, or low
Gastrin levels,	Increased	Low, or normal
Vitamin B12 levels	Decreased	Often normal
Against H. pylori antibodies	Negative, but may be positive	Positive
Endoscopy
The distribution of atrophic mucosa	Corpus and fundus	Antrum, corpus and funds
Histology
Enterochromaffin-like cells	Common	Rare
Oxyntic glad involvement	Common	Rare
CgA staining	Positive	Negative
H+-K+ ATPase antibody Staining	Negative	Positive, but may be negative
Risk of gastric tumor	Gastric carcinoid	Gastric cancer

AAG: autoimmune atrophic gastritis; APCAs: anti-parietal cell antibodies; AIFAs: anti-intrinsic factor antibodies; PG I: pepsinogen I; PG II: pepsinogen II; CgA: chromogranin A.