Rapid progression of colonic mucinous adenocarcinoma with immunosuppressive condition: A case report and review of literature

Table 3 Summary of colorectal cancer after organ transplantation

No.	Ref.	Immunosuppressant	No. of cases	CRC (occurrence rate, %)	Yr to diagnosis (median, range)	Lesion				SIR	95%CI
						Proximal colon (%)	Distal colon (%)	Rectum (%)	UD (%)
1	Safaeian et al[20]	AZA, CsA, MMF, TAC	224098	790 (0.3)	N/A	408 (51.6)	195 (24.7)	146 (18.5)	41 (5.2)	1.12	1.04-1.20
2	Huo et al[21]	N/A	2105122	53 (0.003)	N/A	N/A	N/A	N/A	N/A	1.82	1.59-2.09
3	Engels et al[22]	N/A	175732	627 (0.4)	N/A	N/A	N/A	N/A	N/A	1.24	1.15-1.34
4	Buell et al[23]	AZA, CsA, MMF, TAC	13000	141 (1.1)	N/A	N/A	N/A	N/A	N/A	1.94	1.64-2.29
5	Aberg et al[24]	CsA, TAC, antibody	540	2 (0.4)	N/A	N/A	N/A	N/A	N/A	1.59	0.19-5.74
6	Merchea et al[26]	AZA, CsA, MMF, TAC, steroid	3946	20 (0.5)	8.7 (0.4-19)	14 (70)	4 (20)	2 (10)	0 (0)	N/A	N/A
7	Rompianesi et al[27]	N/A	8178	34 (0.4)	5.6 (3.8-8.8)	17 (50)	9 (26.5)	8 (23.5)	0 (0)	0.92	0.69-1.20
8	Aigner et al[28]	AZA, CsA, MMF, TAC, steroid	3595	9 (0.3)	5.3 (1.5-10)	4	1	4	0 (0)	N/A	N/A
9	Rademacher et al[29]	AZA, CsA, MMF, TAC, steroid	1616	22 (1.3)	8.2 (0.3-19.9)	N/A	N/A	N/A	N/A	1.9	1.2-2.9
10	Haagsma et al[30]	N/A	174	3 (1.7)	7.9 (5.9-16.7)	N/A	N/A	N/A	N/A	N/A	N/A
11	Park et al[31]	CsA, TAC, Sirolimus, AZA, MMF	360	4 (1.1)	N/A	N/A	N/A	N/A	N/A	N/A	N/A

AZA: Azathioprine; CsA: Cyclosporine; MMF: Mycophenolate mofetil; TAC: Tacrolimus; CRC: Colorectal cancer; UD: Undetermined; SIR: Standardized incidence ratio; N/A, data not available.