Midazolam dose is associated with recurrence of paradoxical reactions during endoscopy

Table 3 Multivariable analysis of risk factors for recurrent paradoxical reactions in 350 participants

	OR	95%CI		P value1
Age	1.005	0.978	1.034	0.7025
Female gender (vs male)	1.521	0.731	3.164	0.262
BMI	1.072	0.992	1.158	0.0797
Smoking
Ex-smoker (vs never smoker)	1.07	0.484	2.366	0.8673
Current smoker (vs never smoker)	1.311	0.572	3.007	0.522
Alcohol
Moderate (vs none to minimal)	1.283	0.683	2.409	0.438
Heavy (vs none to minimal)	0.925	0.413	2.075	0.8504
Medication2: Yes (vs no)	1.055	0.242	4.598	0.9436
Endoscope type: H260 (vs H290)	1.405	0.854	2.312	0.1808
Endoscopist experience
Expert (vs less experienced)	0.712	0.403	1.256	0.2407
Highly expert (vs less experienced)	0.822	0.434	1.557	0.5477
Δ Midazolam dose difference (total) (mg)	1.213	1.099	1.338	0.0001

¹Adjusted for age, sex, body mass index, smoking, alcohol, medication, endoscope type, and endoscopist’s experience.

²Medication: Antidepressants, anxiolytics, or hypnotics. Δ Midazolam dose difference = midazolam dose (mg) - previous midazolam dose (mg). OR: Odds ratio; CI: Confidence interval; BMI: Body mass index.