Time to give up traditional methods for the management of gastrointestinal neuroendocrine tumours

Table 1 Classification and grading criteria for neuroendocrine neoplasms

Type of NET	Differentiation	Grade	Mitotic Index	Proliferative index: Ki-67
NET, grade 1	Well-differantiated	Low	< 2	< 3
NET, grade 2		Intermediate	2-20	3-20
NET, grade 3		High	> 20	> 20
NEC, grade 3	Poorly-differantiated	High	> 20	> 20
Small cell type; Large cell type
MINENs	Well or poorly differentiated	Variable

MINEN: Mixed neuroendocrine neoplasm; NET: Neuroendocrine tumor.