Validated tool for early prediction of intensive care unit admission in COVID-19 patients

Table 2 Multivariate logistic regression models of risk severity in the training cohort

Feature	Univariate logistic regression		Multivariate LR
	OR (95%CI)	P value	OR (95%CI)	P value
Age, yr	2.64 (2.06–3.37)	< 0.001	2.68 (1.99-3.61)	< 0.001
BNP	1.53 (1.34–1.75)	< 0.001
CRP	2.01 (1.68–2.40)	< 0.001
D-dimer	1.13 (1.06–1.20)	< 0.001
Albumin	0.37 (0.29–0.48)	< 0.001	0.62 (0.46–0.83)	0.001
Hcv_ab	1.005 (0.999–1.011)	0.083
AST	1.50 (1.29–1.75)	< 0.001
CysC	1.32 (1.19–1.46)	< 0.001
APTT	1.80 (1.45–2.23)	< 0.001
Cr	1.10 (1.05–1.16)	< 0.001	1.11 (1.06–1.15)	< 0.001
Myoglobin	1.64 (1.44–1.88)	< 0.001
CK	1.12 (1.05–1.20)	< 0.001
PCT	1.008 (1.003–1.014)	< 0.001
Tp_ab	1.001 (0.999–1.003)	0.231
BUN	1.70 (1.44–1.99)	< 0.001
PT	1.65 (1.36–1.99)	< 0.001
LAC	0.81 (0.68–0.98)	0.012
LDH	2.36 (1.91–2.93)	< 0.001	2.09 (1.61–2.7)	< 0.001
Hgb	0.69 (0.58–0.82)	< 0.001
GLU	1.28 (1.15–1.44)	< 0.001	1.16 (1.02–1.31)	0.023
HBeAg	1.010 (0.920–1.108)	0.156
HBsAg	0.999 (0.995–1.003)	0.577
NLR	1.90 (1.61–2.25)	< 0.001	1.27 (1.06–1.51)	0.008

APTT: Activated partial thromboplastin time; AST: Aspartate transaminase; BNP: Brain natriuretic peptide; BUN: Blood urea nitrogen; CI: Confidence interval; CK: Creatine kinase; Cr: Creatinine; CRP: C-reactive protein; CysC: Cystatin C; GLU: Glucose; HBeAg: Hepatitis B e antigen; HBsAg: Hepatitis B surface antigen Hcv_ab: Hepatitis C virus antibody; Hgb: Hemoglobin; LAC: Lactate; LDH: Lactate dehydrogenase; LR: Logistic regression; NLR: Neutrophil-to-lymphocyte ratio; OR: Odds ratio; PCT: Procalcitonin; PT: prothrombin time; Tp_ab: Treponema pallidium antibody.