Review
Copyright ©The Author(s) 2021.
World J Clin Cases. Sep 26, 2021; 9(27): 7973-7985
Published online Sep 26, 2021. doi: 10.12998/wjcc.v9.i27.7973
Table 1 Classification of neuroendocrine neoplasms according to World Health Organization criteria

Mitotic rate (mitoses/mm2)
Ki-67 index
Differentiation
Neuroendocrine tumor, Grade 1< 2< 3%Well
Neuroendocrine tumor, Grade 22-203%-20%Well
Neuroendocrine tumor, Grade 3> 20> 20%Well
Neuroendocrine carcinoma, small-cell type> 20> 20%Poor
Neuroendocrine carcinoma, large-cell type> 20> 20%Poor
Mixed neuroendocrine–non-neuroendocrine neoplasmVariableVariableVariable