Role of international normalized ratio in nonpulmonary sepsis screening: An observational study

Table 4 Performance characteristics of the single biomarker for diagnosing sepsis

	AUC (95%CI)	Cut-off value	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)
WBC (× 109/L)	0.599 (0.508-0.684)	11.29	48.57	72.41	68	53.8
NLCR	0.83 (0.754-0.891)	11.86	81.43	77.59	81.4	77.6
INR (× 109/L)	0.918 (0.857-0.959)	1.22	90	84.48	87.5	87.5
PLT	0.841 (0.766-0.9)	180	80	82.76	84.8	77.4
PT (s)	0.868 (0.796-0.921)	15.3	80	87.93	88.9	78.5
qSOFA ≥ 2	0.638 (0.548-0.721)		28.57	79.31	62.5	47.9

AUC: Area under curves; INR: International normalized ratio; NLCR: Neutrophil-lymphocyte count ratio; NPV: Negative predictive value; PLT: Platelet; PT: Prothrombin time; PPV: Predictive positive value; qSOFA: Quick Sequential “Sepsis-related” Organ Failure Assessment; WBC: White blood cell; 95%CI: 95% confidence intervals.