Novel model combining contrast-enhanced ultrasound with serology predicts hepatocellular carcinoma recurrence after hepatectomy

Table 1 Basic characteristics

	Total	Non-recurrence	Recurrence	P value
Diameter (mean ± SD, cm)	3.9 ± 2.3	3.2 ± 1.5	4.8 ± 2.8	< 0.001
Age (mean ± SD, yr)	55.7 ± 11.2	54.9 ± 11.3	56.7 ± 11.1	0.17
ALT (mean ± SD, U/L)	35.5 ± 30.1	31.5 ± 21.4	40.7 ± 38.1	0.016
AST (mean ± SD, U/L)	36.1 ± 34.6	30.4 ± 15.3	43.5 ± 48.9	0.11
PLT (mean ± SD, /L)	150.2 ± 66.4	145.0 ± 62.9	157.2 ± 70.4	0.16
ALB (mean ± SD, g/L)	38.8 ± 4.6	38.7 ± 4.8	38.9 ± 4.3	0.94
TBIL (mean ± SD, μmol/L)	17.6 ± 8.9	16.9 ± 8.3	18.6 ± 9.6	0.16
Cr (mean ± SD, μmol/L)	74.0 ± 17.5	74.3 ± 19.8	73.6 ± 14.0	0.42
PT (mean ± SD, s)	13.8 ± 1.2	13.9 ± 1.2	13.8 ± 1.3	0.49
PTA(mean ± SD, )	92.6 ± 14.9	92.3 ± 13.7	92.9 ± 16.3	0.91
INR (mean ± SD)	1.1 ± 0.1	1.1 ± 0.1	1.1 ± 0.1	0.97
Start time (mean ± SD, s)	16.8 ± 3.7	17.1 ± 3.9	16.5 ± 3.5	0.17
Peak time (mean ± SD, s)	24.1 ± 5.6	24.1 ± 5.3	24.0 ± 6.0	0.45
Iso-time (mean ± SD, s)	39.1 ± 16.9	40.9 ± 19.8	36.8 ± 11.7	0.079
Washout time (mean ± SD, s)	94.8 ± 63.3	98.5 ± 63.3	89.8 ± 63.3	0.11
Sex, n (%)
Male	238 (81.5)	129 (77.7)	109 (86.5)	0.068
Female	54 (18.5)	37 (22.3)	17 (13.5)
LIRADS, n (%)
3	10 (3.4)	8 (4.8)	2 (1.6)	< 0.001
4	176 (60.3)	118 (71.1)	58 (46.0)
5	95 (32.5)	37 (22.3)	58 (46.0)
6	11 (3.8)	3 (1.8)	8 (6.3)
AFP [n (%), μg/L]
< 20	193 (66.1)	133 (80.1)	60 (47.6)	< 0.001
20-200	32 (11.0)	13 (7.8)	19 (15.1)
> 200	67 (22.9)	20 (12.0)	47 (37.3)
Enhancement type, n (%)
Non-fast-in fast-out	42 (14.4)	24 (14.5)	18 (14.3)	1.00
Fast-in fast-out	250 (85.6)	142 (85.5)	108 (85.7)
Wash-in type, n (%)
Non-fast-in	4 (1.4)	2 (1.2)	2 (1.6)	1.00
Fast-in	288 (98.6)	164 (98.8)	124 (98.4)
Washout type, n (%)
Non-fast-out	80 (27.4)	41 (24.7)	39 (31.0)	0.29
Fast-out	212 (72.6)	125 (75.3)	87 (69.0)
Enhancement type, n (%)
Homogeneous enhancement	223 (76.4)	127 (76.5)	96 (76.2)	1.00
Inhomogeneous enhancement	69 (23.6)	39 (23.5)	30 (23.8)
Location, n (%)
Half liver	261 (89.4)	148 (89.2)	113 (89.7)	1.00
Non-half liver	31 (10.6)	18 (10.8)	13 (10.3)

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelet; AFP: Alpha-fetoprotein; ALB: Albumin; TBIL: Total bilirubin; Cr: Serum creatinine; PT: Prothrombin time; PTA: Prothrombin time activity; INR: International normalized ratio; LIRADS: Liver imaging reporting and data system.