Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer

doi:10.12998/wjcc.v9.i24.6999

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Cases. Aug 26, 2021; 9(24): 6999-7008
Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.6999

Table 4 Discrepancy between the results of microsatellite instability test and immunohistochemistry

MSI status	IHC							(n = 32)
	MLH1	MSH2	PMS2	MSH6	Causes of discrepancy			Overall
	MLH1	MSH2	PMS2	MSH6	PF	LE	Unknown	Overall
MSI-H	+	+	+	+	0	0	5	5
MSS	Loss	+	Loss	+	6	1¹	4	11
	+	Loss	+	Loss	0	1¹	5	6
	+	+	Loss	+	2	1	1	4
	+	+	+	Loss	0	0	3	3
	Loss	+	+	+	2	0		2
	Loss	Loss	+	Loss	1	0		1

MSI-H: High-frequency microsatellite instability; MSS: Microsatellite stable; “+”: Retained expression of protein; Loss: Loss of MMR protein expression; PF: Poor fixation; LE: Low expression (i.e., ¹radiotherapy).

Citation: Kim JB, Kim YI, Yoon YS, Kim J, Park SY, Lee JL, Kim CW, Park IJ, Lim SB, Yu CS, Kim JC. Cost-effective screening using a two-antibody panel for detecting mismatch repair deficiency in sporadic colorectal cancer. World J Clin Cases 2021; 9(24): 6999-7008
URL: https://www.wjgnet.com/2307-8960/full/v9/i24/6999.htm
DOI: https://dx.doi.org/10.12998/wjcc.v9.i24.6999