Expression of caspase-3 and hypoxia inducible factor 1α in hepatocellular carcinoma complicated by hemorrhage and necrosis

Table 3 Relationship between expression of caspase-3 and hypoxia inducible factor 1α and clinical pathology of hepatocellular carcinoma, n (%)

Clinicopathological feature	Cases	Positive expression rate of caspase-3	χ2	P value	Positive expression rate of HIF-1α	χ2	P value
Age (yr)			0.499	0.480		0.017	0.896
≤ 50	45	5 (11.11)			33 (73.33)
> 50	43	7 (16.28)			31 (72.09)
Sex			0.288	0.591		0.121	0.728
Male	45	7 (15.56)			32 (71.11)
Female	43	5 (11.63)			32 (74.42)
Tumor diameter			0.013	0.909		1.305	0.253
< 5 cm	50	7 (14.00)			34 (68.00)
≥ 5 cm	38	5 (13.16)			30 (78.95)
TNM stage			4.639	0.031		5.502	0.019
I-II	52	11 (21.15)			33 (63.46)
III	36	1 (2.78)			31 (86.11)
Differentiation degree			0.506	0.477		0.018	0.892
High differentiation	32	4 (12.50)			23 (71.88)
Medium/low differentiation	56	8 (14.29)			41 (73.21)
Lymph node metastasis			7.723	0.005		11.619	0.001
Yes	40	1 (2.50)			22 (55.00)
No	48	11 (22.92)			42 (87.50)
HbsAg positivity			0.000	1.000		0.497	0.481
Yes	72	10 (13.89)			54 (75.00)
No	16	2 (12.50)			10 (62.50)
Portal vein tumor thrombus			0.013	0.909		13.617	0.035
Yes	50	7 (14.00)			44 (88.00)
No	38	5 (13.16)			22 (52.63)

HbsAg: Hepatitis B surface antigen; TNM: Tumor node metastasis; HIF-1α: Hypoxia inducible factor 1α.