Innate immunity – the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

Table 3 Correlations between TLR9 rs352140 polymorphism and laboratory parameters in the two groups

CC genotype of TLR9 rs 352140, n = 35	Study group, n = 11, mean ± SD (median)	Control group, n = 24, mean ± SD (median)	P value
Hemoglobin (g/dL)	14.17 ± 3.300 (13.10)	13.57 ± 1.600 (13.55)	0.9001
Leucocytes (10³/µL)	9.076 ± 3.074 (9.76)	8.522 ± 2.787 (8.01)	0.5571
Lymphocytes (10³/µL)	2.525 ± 0.6571 (2.500)	2.414 ± 0.844 (2.385)	0.704
Neutrophils (10³/µL)	5.600 ± 2.727 (5.72)	5.151 ± 2.967 (4.49)	0.7091
Eosinophils (10³/µL)	0.1831 ± 0.1207 (0.18)	0.2246 ± 0.2376 (0.11)	0.8441
ESR (mm/h)	15.64 ± 16.14 (11.00)	10.04 ± 11.13 (6.00)	0.2251
Iron µmol/L)	17.35 ± 11.07 (12.52)	16.72 ± 8.777 (13.91)	0.8721
AST (U/L)	22.43 ± 6.421 (20.80)	21.84 ± 6.481 (21.30)	0.803
ALT (U/L)	13.64 ± 4.125 (13.20)	14.16 ± 6.511 (12.60)	0.9011
GGT (U/L)	11.64 ± 3.443 (11.00)	12.38 ± 2.667 (12.00)	0.1691
NLR	2.374 ± 1.426 (1.660)	2.620 ± 2.150 (1.845)	0.8591
CT genotype of TLR9 rs 352140, n = 84	Study group, n = 21, mean ± SD (median)	Control group, n = 63, mean ± SD (median)	P value
Hemoglobin (g/dL)	13.37 ± 1.001 (13.00)	13.49 ± 1.435 (13.70)	0.4351
Leucocytes (10³/µL)	7.580 ± 2.331 (7.55)	6.826 ± 2.262 (6.64)	0.0751
Lymphocytes (10³/µL)	2.545 ± 0.6196 (2.56)	2.546 ± 0.8016 (2.45)	0.7131
Neutrophils (10³/µL)	4.032 ± 2.055 (3.85)	3.488 ± 1.898 (3.11)	0.2531
Eosinophils (10³/µL)	0.272 ± 0.3047 (0.175)	0.218 ± 0.3075 (0.110)	0.3321
ESR (mm/h)	10.48 ± 6.668 (9.00)	8.841 ± 5.995 (7.00)	0.2881
Iron µmol/L)	14.84 ± 5.340 (15.00)	14.87 ± 5.832 (15.13)	0.985
AST (U/L)	19.22 ± 4.518 (19.50)	23.54 ± 13.10 (20.10)	0.1741
ALT (U/L)	12.73 ± 3.659 (11.80)	15.93 ± 13.55 (13.10)	0.1281
GGT (U/L)	11.10 ± 3.646 (11.00)	12.76 ± 4.950 (11.00)	0.0941
NLR	1.664 ± 1.028 (1.330)	1.489 ± 0.8915 (1.300)	0.4921
TT genotype of TLR9 rs 352140, n = 36	Study group, n = 16, mean ± SD (median)	Control group, n = 20, mean ± SD (median)	P value
Hemoglobin (g/dL)	13.80 ± 1.332 (13.50)	13.16 ± 0.9517 (13.20)	0.101
Leucocytes (10³/µL)	7.660 ± 1.410 (7.510)	6.434 ± 1.618 (6.045)	0.022
Lymphocytes (10³/µL)	2.383 ± 0.8418 (2.305)	2.254 ± 0.5870 (2.210)	0.590
Neutrophils (10³/µL)	4.221 ± 1.537 (3.865)	3.232 ± 1.472 (2.745)	0.0291
Eosinophils (10³/µL)	0.3844 ± 0.5999 (0.110)	0.2145 ± 0.3203 (0.175)	0.7861
ESR (mm/h)	9.063 ± 5.709 (8.50)	10.00 ± 6.720 (7.00)	0.7471
Iron µmol/L)	15.39 ± 5.304 (14.45)	16.50 ± 8.347 (13.36)	0.646
AST (U/L)	21.82 ± 9.044 (20.25)	22.44 ± 8.341 (21.50)	0.831
ALT (U/L)	11.88 ± 4.311 (10.20)	15.65 ± 9.539 (13.35)	0.1071
GGT (U/L)	11.63 ± 2.986 (11.00)	12.50 ± 3.846 (12.50)	0.6421
NLR	2.276 ± 1.933 (1.555)	1.559 ± 0.8576 (1.130)	0.2321

¹Mann-Whitney test.

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CC: Homozygous CC genotype of TLR9 rs352140 polymorphism; CT: Heterozygous CT genotype of TLR9 rs352140 polymorphism; ESR: Erythrocyte sedimentation rate; GGT: Gamma-glutamyl transpeptidase; NLR: Neutrophil/lymphocyte ratio; TT: Homozygous TT genotype of TLR9 rs352140 polymorphism, estimated significance value obtained from non-parametric.