Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome in a Chinese family: A case report and review of literature

Figure 3 Type of gene mutation and relationship between gene mutation sites and effective drugs. A: Types of gene mutation. Ten gene mutations of pyogenic arthritis, pyoderma gangrenosum, and acne have been reported worldwide. A230T, E250Q, and E250K are the most common mutations; B: Fifteen drugs with a good efficacy were found, including corticosteroids, azathioprine, sulfasalazine, leflunomide, tumor necrosis factor-α inhibitors, interleukin-1β antagonist, etc. This figure summarizes effective drugs based on their gene mutation sites.