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©The Author(s) 2021.
World J Clin Cases. Aug 6, 2021; 9(22): 6357-6379
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6357
Published online Aug 6, 2021. doi: 10.12998/wjcc.v9.i22.6357
Table 2 Meta-analysis results
Outcome indicators | No. of study | Patients (n) | HR/OR/SMD (95%CI) | P value | Heterogeneity | ||||
NAC | non-NAC | χ2 | I² | P value | |||||
5-year overall survival | 22 | 2580 | 4218 | 0.49 (0.39-0.61) | P < 0.01 | 14.38 | 0.00% | P = 0.853 | |
5-year disease free survival | 13 | 1643 | 2864 | 0.48 (0.36-0.63) | P < 0.01 | 5.68 | 0.00% | P = 0.931 | |
Duration of surgery | 8 | 1980 | 2396 | 0.41 (0.01-0.82) | P < 0.05 | 172.79 | 95.90% | P = 0.000 | |
Number of liver metastases | 12 | 1017 | 1096 | 0.73 (0.02-1.43) | P < 0.05 | 549.46 | 98.00% | P = 0.000 | |
Blood loss during surgery | 6 | 474 | 646 | 0.53 (-0.05-1.10) | P = 0.072 | 90.12 | 94.50% | P = 0.000 | |
Length of hospital stay (d) | 6 | 605 | 565 | 0.01 (-0.61-1.02) | P = 0.624 | 184.79 | 97.30% | P = 0.000 | |
Size of largest metastases (cm) | 13 | 1226 | 1539 | 0.03 (-0.31-0.30) | P = 0.980 | 168.39 | 92.90% | P = 0.000 | |
Synchronous metastases | 19 | 2355 | 2553 | 1.17 (0.90-1.58) | P = 0.221 | 43.91 | 65.80% | P = 0.000 | |
Major liver resection | 14 | 2780 | 3133 | 1.06 (0.97-1.22) | P = 0.143 | 5.21 | 0.00% | P = 0.970 | |
Lymph node metastasis | 16 | 1523 | 2128 | 1.24 (1.07-1.43) | P < 0.05 | 29.26 | 49.50% | P = 0.013 | |
R0 liver resection | 7 | 723 | 976 | 0.85 (0.61-1.18) | P = 0.336 | 6.29 | 4.60% | P = 0.391 | |
Perioperative complications | 17 | 2886 | 3161 | 1.00 (0.76-1.31) | P = 0.980 | 51.82 | 69.10% | P = 0.000 | |
Bile leakage | 10 | 2244 | 2364 | 1.10 (0.84-1.43) | P = 0.481 | 4.77 | 0.00% | P = 0.782 | |
Surgical site infection | 8 | 2065 | 2056 | 0.94 (0.76-1.16) | P = 0.571 | 9.68 | 27.70% | P = 0.208 | |
Liver failure | 7 | 2025 | 1939 | 1.04 (0.76-1.42) | P = 0.813 | 5.77 | 13.40% | P = 0.329 | |
Blood transfusion | 5 | 1805 | 1710 | 1.07 (0.90-1.29) | P = 0.438 | 5.95 | 32.80% | P = 0.203 |
- Citation: Zhang Y, Ge L, Weng J, Tuo WY, Liu B, Ma SX, Yang KH, Cai H. Neoadjuvant chemotherapy for patients with resectable colorectal cancer liver metastases: A systematic review and meta-analysis. World J Clin Cases 2021; 9(22): 6357-6379
- URL: https://www.wjgnet.com/2307-8960/full/v9/i22/6357.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i22.6357