Prediction of presence and severity of coronary artery disease using prediction for atherosclerotic cardiovascular disease risk in China scoring system

Table 1 Clinical and demographical characteristics of patients categorized by Gensini score

	Gensini score = 0	Low-Gensini score	High-Gensini score	P value1	P value	P value	P value
	0	7 (4, 11)	34 (24, 52)		(Group 1-2)	(Group 1-3)	(Group 2-3)
Number of patients	1601	2628	2584
Age (yr)	62 (55, 69)	64 (57, 69)	67 (61, 73)	< 0.001	< 0.001	< 0.001	< 0.001
Male, n (%)	826 (51.6)	1474 (56.1)	1790 (69.3)	< 0.001	< 0.001	< 0.001	< 0.001
Waist circumference	82 (80, 87)	82 (80, 87)	82 (80, 87)	< 0.001	0.693	0.002	0.002
BMI, kg/m2	24.4 (22.1, 26.8)	24.3 (22.2, 26.6)	24.2 (22.2, 26.3)	0.028	0.282	0.047	0.284
Hypertension, n (%)	756 (47.2)	1441 (54.8)	1724 (66.7)	< 0.001	< 0.001	< 0.001	< 0.001
DM, n (%)	194 (12.1)	406 (15.4)	658 (25.5)	< 0.001	< 0.001	< 0.001	< 0.001
Smoking, n (%)	228 (14.2)	427 (16.2)	514 (19.9)	< 0.001	0.08	< 0.001	0.001
Family history of ASCVD	4 (0.2)	35 (1.3)	110 (4.3)	< 0.001	< 0.001	< 0.001	< 0.001
EF, %	55.65 (38, 65.09)	68 (62.9, 72.7)	66.8 (61.3, 72)	< 0.001	< 0.001	< 0.001	< 0.001
Glucose, mmol/L	5.45 (4.92, 6.39)	5.53 (4.95, 6.60)	5.76 (5.07, 7.15)	< 0.001	< 0.001	< 0.001	< 0.001
eGFR	93.3 (80.9, 102.1)	91.5 (80, 100)	88 (74, 97.9)	< 0.001	< 0.001	< 0.001	< 0.001
NT-ProBNP	95 (45, 320)	79 (40, 209.75)	131 (59, 377.75)	< 0.001	< 0.001	< 0.001	< 0.001
Triglyceride	4.34 (3.64, 5.059)	4.19 (3.45, 5.03)	4.099 (3.45, 4.97)	0.026	0.885	0.029	0.019
TC	1.39 (0.99, 1.99)	1.38 (1, 1.9775)	1.45 (1.03, 2.04)	0.012	0.001	< 0.001	0.189
LDL-C	2.33 (1.74, 2.88)	2.19 (1.62, 2.87)	2.16 (1.64, 2.83)	0.03	< 0.001	< 0.001	0.687
HDL-C	0.94 (0, 1.11)	0.9325 (0, 1.1)	0.88 (0, 1.03)	< 0.001	0.092	< 0.001	< 0.001
China-PAR	5.3 (3.1, 7.9)	6 (3.8, 8.9)	8.5 (5.8, 12.2)	< 0.001	< 0.001	< 0.001	< 0.001
< 5%, n (%)	744 (46.5)	1009 (38.4)	454 (17.6)	< 0.001	< 0.001	< 0.001	< 0.001
5%-10%, n (%)	616 (38.5)	1115 (42.4)	1150 (44.5)	< 0.001	< 0.001	< 0.001	< 0.001
> 10%, n (%)	241 (15.1)	504 (19.2)	980 (37.9)	< 0.001	< 0.001	< 0.001	< 0.001

Values are expressed as the mean ± SD or n (%), median (minimum–maximum).

¹ANOVA, Kruskal–Wallis, or Pearson chi-square test was used to compare variables among three groups. CAD: Coronary artery disease; BMI: Body mass index; DM: Diabetes mellitus; ASCVD: Atherosclerotic cardiovascular disease; EF: Ejection fraction; eGFR: Epidermal growth factor receptor; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; China-PAR: Prediction for atherosclerotic cardiovascular disease risk in China.