Revisiting delayed appendectomy in patients with acute appendicitis

Table 1 Clinical trials and meta-analyses comparing primary antibiotic treatment vs surgery for acute appendicitis

Ref.	Publishing year	Study design	Patients in NOM (n)	Age (yr)	Initially successful	Recurrence rate
Harnoss et al[10]	2017	Meta-analysis	1312	13-75	89.2%	1-yr: 27.4%
Podda et al[11]	2019	Meta-analysis	1743	Unrestricted	91.5%	1-yr: 19.2%
Eriksson et al[13]	1995	RCT	20	≥ 18	95%	1-yr: 37%
APPAC study[14,15]	2015	Multicentre RCT	257	≥ 18	94%	1-yr: 27%; 5-yr: 39.1%;
Minneci et al[16]	2016	Prospective cohort	37	7-17	94.6%	30-d: 5.4%; 1-yr: 18.9%
Georgiou et al[72]	2017	Meta-analysis	413	< 18	97%	Adjusted: 14%
Joo et al[73]	2017	Prospective observational	20	Pregnant women	85%	10%

The table is not an exhaustive list and the scope has been restricted to references that are discussed in the main text. NOM: Nonoperative management; RCT: Randomised controlled trial.