Copyright
©The Author(s) 2021.
World J Clin Cases. Jan 16, 2021; 9(2): 308-320
Published online Jan 16, 2021. doi: 10.12998/wjcc.v9.i2.308
Published online Jan 16, 2021. doi: 10.12998/wjcc.v9.i2.308
Table 2 Central receptor involved in bile acid signaling
Receptor | Tissue | Cardiovascular tissue | Ligand | Regulatory mechanism | Direct action | Ref. |
FXR | Liver, kidney, gastrointestinal | Arteries, cardiomyocytes | CDCA, LCA, DCA | Regulates BSEP expression and participates in the process of liver injury, activates I-BABP expression to mediate cholesterol secretion, inhibits vascular inflammation, decreases lipogenesis synthesis, increases lipoprotein clearance to prevent atherosclerosis, ameliorates post-MI cardiac dysfunction and remodeling | No | [14-16] |
PXR,VDR | Liver | t-Tubulescardiomyocytes | LCA | Down-regulates CYP7A1 expression to eliminate BA toxicity, maintains lipid metabolism, regulates intracellular calcium flow and contractile forces, maintains the normal operation of cardiomyocytes | No | [17-19] |
M | Nervous, intestinal, gastrointestinal | Aorta, cardiomyocytes | TC, LCT, TCA | Stimulates acetylcholine-induced inositol phosphorylation and MAP kinase phosphorylation, inhibits cAMP, amplitude, reduces CM contraction | Yes | [20,21] |
S1P | Liver, nervous, immune | Endothelial smooth muscle, cardiomyocytes | TCA, UDCA | Inhibits formation of cAMP and antagonizes adrenergic receptor-mediated contractile force, protects heart from ischemia/reperfusion injury, involved in remodeling and differentiation of cardiac fibroblasts | No | [22,23] |
TGR5 | Liver, glands, fat, muscle, enteric, immune | Aortic endothelial | CA, DCA, CDCA, TLCA, TCDCA | Inhibits the secretion of TNF induced by LPS, downregulates GSK3 and upregulates PKB associated with cardiac hypertrophy, metabolic transformation of energy in cardiomyocytes | Yes | [24,25] |
BK channel | Liver, brain | Endothelial, cardiomyocytes | LCA | Cause vasodilation in liver and cerebral artery, plays role in diabetes, through mitochondrial BK channels confer cardioprotection | Yes | [26-28] |
- Citation: Zhang R, Ma WQ, Fu MJ, Li J, Hu CH, Chen Y, Zhou MM, Gao ZJ, He YL. Overview of bile acid signaling in the cardiovascular system. World J Clin Cases 2021; 9(2): 308-320
- URL: https://www.wjgnet.com/2307-8960/full/v9/i2/308.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v9.i2.308