SMAC exhibits anti-tumor effects in ECA109 cells by regulating expression of inhibitor of apoptosis protein family

Figure 4 Effects of LCL161 on apoptotic signals. Serum-starved ECA109 cells were stimulated with LCL161 (5-20 mmol/L) for 48 h. A: The expression of XIAP, Caspase-3, and Bax was measured by Western blot; B-D: Bar graphs showing quantitative analysis of Western blot analysis (B: XIAP; C: Caspase-3; D: Bax). The bands of proteins were normalized to those of β-actin. mean ± SD. ^aP < 0.05 vs control, ^cP < 0.001 vs control, ^dP < 0.01 vs 5 mmol/L group, ^eP < 0.001 vs 5 mmol/L group.