Impact of continuous positive airway pressure therapy for nonalcoholic fatty liver disease in patients with obstructive sleep apnea

Table 2 Comparison of data between before and after 6 mo of continuous positive airway pressure therapy in obstructive sleep apnea patients with nonalcoholic fatty liver disease

	n	Before CPAP	After 6 mo of CPAP	P value
Demographics
BW (kg)	50	75.6 ± 13.4	74.8 ± 13.0	0.076
BMI (kg/m2)	50	27.6 ± 4.4	27.4 ± 4.4	0.153
Biochemical parameter
AST (U/L)	50	28.2 ± 10.9	24.7 ± 7.5	0.005
ALT (U/L)	50	37.6 ± 19.1	33.1 ± 22.4	0.021
GGT (U/L)	50	45.6 ± 40.0	42.5 ± 40.1	0.299
Albumin (g/dL)	50	4.57 ± 0.35	4.54 ± 0.37	0.445
Uric acid (mg/dL))	50	5.81 ± 1.17	5.79 ± 1.29	0.836
TG (mg/dL)	47	139.5 ± 67.8	126.0 ± 54.8	0.105
LDL-C (mg/dL)	50	133.9 ± 35.9	134.2 ± 45.7	0.949
HDL-C (mg/dL)	50	55.9 ± 12.9	56.1 ± 11.4	0.866
hs-CRP (mg/dL)	49	0.154 ± 0.242	0.152 ± 0.205	0.953
HbA1c (%)	50	6.16 ± 0.78	6.06 ± 0.55	0.120
HOMA-IR	47	2.28 ± 1.73	2.46 ± 1.63	0.369
Serum fibrosis markers
M2BPGi	50	0.507 ± 0.226	0.539 ± 0.314	0.365
Type IV collagen 7s (ng/mL)	50	3.07 ± 0.69	3.09 ± 0.60	0.684
Platelet count (× 104/μL)	49	25.28 ± 6.49	24.78 ± 6.43	0.257
Transient elastography measurements
LSM (kPa)	48	4.61 ± 1.78	4.70 ± 1.94	0.617
CAP (dB/m)	48	304.0 ± 52.2	303.9 ± 44.1	0.987

Data are presented as mean ± standard deviation. Data were examined by a paired t-test or the Wilcoxon signed-rank test, as appropriate. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; BW: Body weight; CAP: Controlled attenuation parameter; CPAP: Continuous positive airway pressure; GGT: γ-glutamyl transpeptidase; HbA1c: Hemoglobin A1c; HDL-C: High-density lipoprotein cholesterol; HOMA-IR: Homeostasis model assessment-insulin resistance; hs-CRP: High-sensitivity C-reactive protein; LDL-C: Low-density lipoprotein cholesterol; LSM: Liver stiffness measurement; M2BPGi: Mac-2-binding protein glycan isomer; m-CI: Mean compliance index; NAFLD: Nonalcoholic fatty liver disease; OSA: Obstructive sleep apnea; TG: Triglycerides.