Minireviews
Copyright ©The Author(s) 2021.
World J Clin Cases. Jul 6, 2021; 9(19): 4980-4989
Published online Jul 6, 2021. doi: 10.12998/wjcc.v9.i19.4980
Table 1 Overview of included papers regarding coronavirus disease 2019
Ref.CountryCitySample size (n)Male, n (%)History of liver disease (%)Abnormal liver bio-chemical indicators at admission or during hospitalization, n (%)
Chu et al[7]ChinaWuhan838464 (55.3)NAElevated ALT 429 (51.1);Elevated AST 429 (51.1); Elevated TBIL 429 (51.1)
Piano et al[8]ItalyNA565357 (63.1)31 (6) Elevated ALT 329 (58);Elevated AST 329 (58); Elevated TBIL 329 (58)
Huang et al[10]ChinaJiangsu26231312 (50)NADecreased albumin levels: 1230 (46.9) on the first laboratory test; 1435 (54.7) on the second test after hospitalization
Huang et al[11]ChinaShenzhen417198 (47.5)21 (5.04)318 (76.3) had abnormal liver test results;90 (21.5) had liver injury during hospitalization.
Fan et al[12]ChinaShanghai14875 (50.7)NA55 (37.2) with abnormal liver function tests on admission;45 (48.4) developed liver functional abnormality 7 d after admission
Wu et al[14]ChinaYanchengWuxi8039 (48.7)NAAbnormal ALT 3 (3.75); Abnormal AST 3 (3.75); Abnormal Alb 2 (2.50)
Da et al[16]United StatesNew York53 (60)NAAbnormal ALT 5 (3.75); Abnormal AST 5 (3.75); Abnormal Alb 4 (2.50)
Da et al[17]United StatesNew York176103 (58.5)NAAbnormal ALT 109 (61.9);Abnormal AST 109 (61.0),
Fu et al[18]ChinaWuhan Fuyang355190 (53.5)16 (4.5)151 (42.5) with cholestasis;101 (28.5) with hepato-cellular injury
Lin et al[19]ChinaChongqing13372 (54.1)17 (12.7)Elevated ALT 31 (23.3);Elevated AST 27 (20.3);
Zou et al[20]ChinaWuhan10555 (52.3)105 (100)Elevated ALT 22 (20.95); Elevated AST 29 (27.62);
Ji et al[21]ChinaNA202113 (55.9) NAElevated ALT 101 (50.0);Elevated AST 34 (16.8); Elevated TBIL 17 (8.4)
Sarin et al[22]NANA228132 (57.8)132 (100)NA
Iavarone et al[23]ItalyLombardy5035 (70)50 (100)Elevated ALT 29 (58);Elevated AST 32 (67)