Evaluation of a five-gene signature associated with stromal infiltration for diffuse large B-cell lymphoma

Figure 4 Overexpression of five hub genes was confirmed in diffuse large B-cell lymphoma. A-E: Correlation analyses between alpha-2-macroglobulin (A2M) (A), cathepsin B (CTSB) (B), fibronectin (FN1) (C), matrix metallopeptidase 9 (MMP9) (D), secreted protein acidic and cysteine-rich (SPARC) (E) expression, and tumor purity were conducted by the Estimation of Stromal and Immune cells in Malignant Tumor tissues using Expression data Score (ESTIMATE) method; F: Expression correlation analysis between CD19 and the five hub genes was conducted in GEPIA. P < 0.05 was considered as statistically different.