Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer

Figure 1 Flow chart of the procedure applied in this study. We identified the differentially expressed (DE) circRNAs, DEmiRNAs and DEmRNAs and then took the intersection of DEmiRNAs and DEmRNAs with the predicted targets of DEcircRNAs and intersected miRNA to obtain the competing endogenous RNA network in the Gene Expression Omnibus (GEO) database, performed GO and KEGG enrichment analyses, and constructed a prognostic subnetwork based on survival analysis in The Cancer Genome Atlas (TCGA) database. ceRNA: Competing endogenous RNA.