Growth hormone cocktail improves hepatopulmonary syndrome secondary to hypopituitarism: A case report

Table 2 Changes of liver function and metabolism before and after hormonal treatment

Blood gas analysis on room air	Baseline	Post-treatment	Liver function	Baseline	Post-treatment	Metabolic parameters	Baseline	Post-treatment
pH (7.35-7.45)	7.42	7.42	Alb (35-52g/L)	43	44	TG (0.45-1.70 mmol/L)	2.14	1.36
PCO2 (35-45 mmHg)	34.0	34.6	Tbil (5.1-22.2 μmol/L)	37.0	30.4	TC (2.85-5.70 mmol/L)	6.71	5.92
PO2 (83-108 mmHg)	37.0	71.1	Dbil (0-6.8 μmol/L)	9.6	7.2	LDL-c (< 3.37 mmol/L)	4.70	4.43
SaO2 (95%-99%)	78%	93.1%	GGT (0-40 U/L)	70	64	HDL-c (0.93-1.81 mmol/L)	0.91	0.80
BE (-3.0 ± 3.0 mmol/L)	-7.2	-2.0	ALP (45-125 U/L)	65	80	Fasting-insulin (5.2 - 17.2 μU/mL)	29.1	26.6
HCO-3 (22.0-27.0 mmol/L)	17.7	22.7	ALT (9-50 U/L)	58	47	Fasting blood glucose (3.9-6.1 mmol/L)	6.00	5.60
P(A-a)O2 (5.0-15.0 mmHg)	70.2	35.7	AST (15-40 U/L)	45	32	HbA1c (4.5%-6.3%)	7.4%	7.1%
Intrapulmonary shunt ratio(1.0%-10.0%)	64.4%	9.0%	PIIINP (< 15.00 ng/mL)	13.50	15.21	Na (135-145 mmol/L)	142	138
			CIV (< 95.00 ng/mL)	356.30	46.88	CRP (< 3.00 mg/L)	5.12	0.79
			HA (< 120.00 ng/mL)	73.50	51.83

BE: Base excess; P_(A-a)O₂: Alveolar–arterial oxygen gradient; Alb: Albumin; TBil: Total bilirubin; DBil: Direct bilirubin; GGT: Gamma-glutamyl transpeptidase; ALP: Alkaline phosphatase; ALT: Alkaline phosphatase; AST: Aspartate aminotransferase; PIIINP: Procollagen III N-terminal peptide; CIV: Collagen type IV; HA: Hyaluronic acid; TG: Triglyceride; TC: Total cholesterol; LDL-c: Low-density lipoprotein cholesterol; HDL-c: High-density lipoprotein cholesterol; HbA1c: Hemoglobin A1c; CRP: C-reactive protein.